In 2014 we published 34 new reviews, updated 9 and published 24 protocols.


Anaesthetic regimens for day-procedure laparoscopic cholecystectomy.

Clonidine premedication for postoperative analgesia in children.

Dexmedetomidine for the management of awake fibreoptic intubation.

Tracheal intubation with a flexible intubation scope versus other intubation techniques for obese patients requiring general anaesthesia.

Neuraxial blockade for the prevention of postoperative mortality and major morbidity: an overview of Cochrane systematic reviews.

Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults.

Continuous interscalene brachial plexus block versus parenteral analgesia for postoperative pain relief after major shoulder surgery.

Intravenous versus inhalational anaesthesia for paediatric outpatient surgery.

Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death.

High-flow nasal cannula therapy for respiratory support in children.

Different regimens of intravenous sedatives or hypnotics for electroconvulsive therapy (ECT) in adult patients with depression.

Femoral nerve blocks for acute postoperative pain after knee replacement surgery.

Heparin versus normal saline for patency of arterial lines.

Neostigmine for reversal of neuromuscular block in paediatric patients.

Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients.

Pressure support versus T-tube for weaning from mechanical ventilation in adults.

Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adult patients.

Thermal insulation for preventing inadvertent perioperative hypothermia.

Air versus saline in the loss of resistance technique for identification of the epidural space.

Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation.

Mannitol versus hypertonic saline for brain relaxation in patients undergoing craniotomy.

Physician anaesthetists versus non-physician providers of anaesthesia for surgical patients.

Continuous positive airway pressure (CPAP) during the postoperative period for prevention of postoperative morbidity and mortality following major abdominal surgery.

Preoperative carbohydrate treatment for enhancing recovery after elective surgery.

Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults.

Cardiopulmonary resuscitation (CPR) plus delayed defibrillation versus immediate defibrillation for out-of-hospital cardiac arrest.

Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.

Glutamine supplementation for critically ill adults.

Perioperative beta-blockers for preventing surgery-related mortality and morbidity.

Intranasal fentanyl for the management of acute pain in children.

Anaesthetic techniques for risk of malignant tumour recurrence.

Interventions for treating inadvertent postoperative hypothermia.

Conservative versus interventional management for primary spontaneous pneumothorax in adults.

Diaries for recovery from critical illness.

Updated reviews:

Incentive spirometry for prevention of postoperative pulmonary complications in upper abdominal surgery.

Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis.

Pulse oximetry for perioperative monitoring.

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children.

Positive end-expiratory pressure (PEEP) during anaesthesia for prevention of mortality and postoperative pulmonary complications.

Bispectral index for improving anaesthetic delivery and postoperative recovery.

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease.

Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients.

Music interventions for mechanically ventilated patients.


Atropine therapy versus no atropine therapy for the prevention of adverse events in paediatric patients undergoing intubation.

Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults.

Emergency cricothyroidotomy for airway management.

Neuromuscular blocking agents for patients with acute respiratory distress syndrome.

Thoracic epidural anaesthesia combined with general anaesthesia versus general anaesthesia alone for one-lung ventilation.

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adult patients with sepsis, severe sepsis and septic shock.

Safety of off-label erythropoiesis-stimulating agents for critically ill patients.

Nitrous oxide-based versus nitrous oxide-free general anaesthesia and accidental awareness during general anaesthesia in surgical patients.

Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia.

Pulmonary perfusion versus no pulmonary perfusion during cardiopulmonary bypass for cardiac surgery.

Videolaryngoscopy versus direct laryngoscopy for adult surgical patients requiring tracheal intubation for general anaesthesia.

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in patients without acute lung injury.

Nurse-led service versus doctor-led service for preoperative assessment in elective surgical patients.

Central venous catheter (CVC) removal for adult patients with candidaemia.

BIS monitoring versus clinical assessment for sedation in mechanically ventilated adult patients in the intensive care unit and its impact on clinical outcomes and resource utilization.

Processed electroencephalogram indices for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures.

Prediction models for the risk of postoperative nausea and vomiting.

Automated mandatory bolus versus basal infusion for maintenance of epidural analgesia in labour.

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis.

Ultrasound-guided arterial cannulation for paediatric patients.

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children.

Total intravenous anaesthesia versus inhalational anaesthesia for transabdominal robotic assisted laparoscopic surgery.

Vascular access specialist teams for device insertion and prevention of failure.

Video-laryngoscopy versus direct laryngoscopy for tracheal intubation in children (excluding neonates).