In 2015 we published 30 new reviews, 12 updated reviews and 12 protocols.Reviews:Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization.Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterizationAdjunctive hyperbaric oxygen for necrotizing fasciitis.Pressure-controlled versus volume-controlled ventilation for acute respiratory failure due to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS)Protocol-directed sedation versus non-protocol-directed sedation to reduce duration of mechanical ventilation in mechanically ventilated intensive care patients.Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients.Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients. Extracorporeal membrane oxygenation for critically ill adults.Adrenaline with lidocaine for digital nerve blocks.Anaesthetic and sedative agents used for electrical cardioversion.Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermiaMelatonin for pre- and postoperative anxiety in adults. The effects of high perioperative inspiratory oxygen fraction for adult surgical patients.Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery.Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients.The use of propofol for procedural sedation in emergency departments. Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia.Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults.Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients.Regional analgesia for improvement of long-term functional outcome after elective large joint replacement.Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia. Drugs for the treatment of nausea and vomiting in adults in the emergency department setting.Noninvasive positive pressure ventilation for acute respiratory failure following upper abdominal surgery.Preoperative inspiratory muscle training for postoperative pulmonary complications in adults undergoing cardiac and major abdominal surgery. Non-pharmacological interventions for sleep promotion in the intensive care unit.Prone position for acute respiratory failure in adults. Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia. Effectiveness and risks of cricoid pressure during rapid sequence induction for endotracheal intubation.Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in patients without acute lung injury.Updated reviews:Early versus late tracheostomy for critically ill patients.Cooling for cerebral protection during brain surgery.Non-pharmacological interventions for assisting the induction of anaesthesia in children. Peribulbar versus retrobulbar anaesthesia for cataract surgery. Selenium supplementation for critically ill adults.Lidocaine for preventing postoperative sore throat.Sub-Tenon's anaesthesia versus topical anaesthesia for cataract surgery. Sedation versus general anaesthesia for provision of dental treatment to patients younger than 18 years.Ultrasound guidance for upper and lower limb blocks. Rocuronium versus succinylcholine for rapid sequence induction intubation. Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Corticosteroids for treating sepsis. Protocols:Ketamine and propofol in combination for adult procedural sedation and analgesia in the emergency department. Nerve blocks or no nerve blocks for pain control after elective hip replacement (arthroplasty) surgery in adults.Regional analgesia versus no regional analgesia for ambulatory hip arthroscopy in adults.Effectiveness and risks of cricoid pressure during rapid sequence intubation.Dexamethasone as an adjuvant to peripheral nerve block. Intraoperative ventilation strategies for obese patients undergoing bariatric surgery. Pharmacological interventions for the treatment of delirium in critically ill patients.Interleukin-6 for diagnosis of sepsis in critically ill adult patients. Cough augmentation techniques for extubation and weaning critically ill patients from mechanical ventilation.Adverse side effects of dexamethasone in surgical patients.Cuffed versus uncuffed endotracheal tubes for general anaesthesia in children aged eight years and under.Interventions for the prevention of acute postoperative pain in adults following brain surgery.